Medicurio
Medicurio
  • 18
  • 3 026 483
Christmas Disease and Hemostasis
Happy holidays everyone! I thought now would be the perfect time to talk about Christmas Disease (Hemophilia B), which is a bleeding disorder. In this video, we'll learn about normal clotting (hemostasis) and what goes wrong in bleeding disorders, as well as the historical impact of this disease and how the most expensive medication in the world is used to treat it.
Script, references, and additional info (including more on the coagulation cascade and other bleeding disorders) can be found on my website: medicurio.ca/2023/12/24/christmas-disease-and-hemostasis/
Timestamps
00:00 Introduction
00:57 The process of hemostasis
02:11 The coagulation cascade
03:57 Symptoms of bleeding disorders
04:41 Pathophysiology of Christmas Disease
05:30 Historical impact (European Royalty, Rasputin, Russian Revolution)
07:32 Treatment of Christmas Disease
09:22 Stephen Christmas and the HIV pandemic
Переглядів: 1 235

Відео

CAR T Cells: Beating Cancer with the Immune System
Переглядів 21 тис.10 місяців тому
Doug Olson's terminal cancer was miraculously cured through genetic modification of his own immune cells. While this sounds like it's straight out of a science fiction novel, many cancer patients are currently receiving this revolutionary new cancer treatment: CAR T cell therapy. Learn about the mechanism, side effects, and the exciting future of CAR T cells in this episode of Medicurio. Please...
Pharmacogenomics: Genes and Medicine
Переглядів 76 тис.4 роки тому
What determines how well or poorly you respond to a medication? This episode of Medicurio highlights the tragic story of a mother and her son to show how genes play such a key role in a medication's effectiveness. I also created a website where you can find all the references to what I say in the video, as well as some extra information that I just couldn't fit into the video. Check it out here...
Opioid Drugs, Part 2: Addiction and Overdose
Переглядів 130 тис.5 років тому
Opioid drugs are a well-known class of drug due to both their ability to kill pain and kill people. Watch part 2 of this two-part series to learn how opioid drugs can cause addiction and overdose, as well as a bit of the history behind the opioid epidemic in North America. Watch Part 1 here: ua-cam.com/video/s60KzN4GJdQ/v-deo.html *Two great articles about the opioid crisis:* The Promotion and ...
Opioid Drugs, Part 1: Mechanism of Action
Переглядів 442 тис.6 років тому
Opioid drugs are a well-known class of drug due to both their ability to kill pain and kill people. Watch part 1 of this two-part series to learn how opioid drugs can manipulate our brain and body into no longer feeling pain and discomfort. Special thanks to Geoffrey Brown for helping research background information for this video! Watch Part 2 here: ua-cam.com/video/vLFf6dlKrqU/v-deo.html Addi...
Celiac Disease and Gluten
Переглядів 105 тис.6 років тому
Gluten-free foods are almost everywhere, and for a good reason - around 1% of the world population suffer from celiac disease and cannot eat gluten. What happens in the body when gluten is eaten, and why does it lead to symptoms like diarrhea, malnutrition, or even anemia? Watch this episode of Medicurio to find out! EXTRA INFORMATION ABOUT CELIAC DISEASE *Are oats safe for celiac patients to e...
Statins and Cholesterol
Переглядів 259 тис.6 років тому
Statins are one of the most highly prescribed and commercially successful drugs in modern society, due to their ability to decrease LDL-cholesterol and lower the risk of developing cardiovascular disease. Learn more about the history, mechanism, and side effects of statins in this episode of Medicurio. Other lipoprotein particles: You may have heard of LDL cholesterol as "bad" cholesterol becau...
Diabetes Mellitus and Insulin
Переглядів 121 тис.7 років тому
One unexpected and unwanted outcome from modernization of society is the increasing prevalence of diabetes mellitus due to changes in lifestyles. Diabetes is a lifelong disease which has no cure, causing terrible suffering among patients and tremendous strain on healthcare systems. Watch this episode of Medicurio to learn more about the cause, symptoms, and treatments available for diabetes. Ra...
Caffeine and Adenosine Receptors
Переглядів 369 тис.7 років тому
We are all familiar with caffeine's stimulatory effects, but how does it actually work? Check out this episode of Medicurio to learn more about the world's most commonly used psychoactive drug. I ended off with saying how caffeine has a variety of medicinal uses, but didn't really go in depth. If you would like to learn more, continue reading. Caffeine as an adjuvant painkiller: Scientists aren...
Strokes and the Brain
Переглядів 36 тис.7 років тому
A person is not the same after a stroke. In many cases, a person's motor skills, personality, and quality of life are negatively impacted because certain areas in the brain are damaged. What is happening in the brain during a stroke? Tune into this episode of Medicurio to learn how to detect, treat, and ultimately prevent strokes from happening to you. Cool links to check out: Heart and Stroke ...
Aspirin and Prostaglandins
Переглядів 306 тис.7 років тому
Aspirin, or acetylsalicylic acid, is one of the oldest and most well-known medications for headaches, fever, pain, and even prevention of heart attack and stroke. How does this drug cause relief of these symptoms? Check out this episode of Medicurio to learn about the quite interesting mechanism of aspirin in the body. Detailed Mechanism of Aspirin: There are two major forms of cyclooxygenase (...
Cushing's Syndrome and Corticosteroids (Part 2)
Переглядів 57 тис.7 років тому
Corticosteroid medications are commonly used to treat many types of diseases, ranging from asthma to arthritis. Many people, after taking corticosteroid medications for long periods of time, begin to gain weight, have high blood pressure, and become weaker, a set of symptoms known as Cushing's Syndrome. Tune into this episode of Medicurio to learn why these symptoms occur and how Cushing's Synd...
Addison's Disease and Corticosteroids (Part 1)
Переглядів 91 тис.7 років тому
Corticosteroids are essential molecules in our body that regulate body functions such as blood pressure and energy production. Too little of these molecules will obviously lead to negative consequences, but what are they and why do they occur? Join me in this episode of Medicurio where we will discuss Addison's Disease. Cool websites to check out on Addison's disease: The Canadian Addison Socie...
Duchenne Muscular Dystrophy and Dystrophin
Переглядів 396 тис.7 років тому
Duchenne Muscular Dystrophy (DMD) is an genetic muscle-wasting disease that leads to disability and early death. In all cases of this disease, the gene for a protein known as dystrophin is mutated. How does a dysfunctional dystrophin gene cause DMD? Find out in this episode of Medicurio. Interesting to note: Becker's Muscular Dystrophy is a similar disease, but with much milder symptoms. People...
Gouty Arthritis (Gout) and Uric Acid
Переглядів 325 тис.7 років тому
Gouty arthritis, or gout, is an extremely painful disease that affects the joints of the elderly, the obese, and the diabetics. Crystals of uric acid are found in these damaged joints. Why do these crystals form, and how are they linked to the excruciating pain experienced by those with gout? Find out more in this episode of Medicurio. Informative websites to check out about gout: Gout and Uric...
Multiple Sclerosis and the Myelin Sheath
Переглядів 66 тис.7 років тому
Multiple Sclerosis and the Myelin Sheath
Parkinson's Disease and the Basal Ganglia
Переглядів 104 тис.7 років тому
Parkinson's Disease and the Basal Ganglia
Cystic Fibrosis and the Mucociliary System
Переглядів 122 тис.7 років тому
Cystic Fibrosis and the Mucociliary System

КОМЕНТАРІ

  • @kshafmazhar1000
    @kshafmazhar1000 День тому

    best explanation ever

  • @KhadoojaAlshiekh
    @KhadoojaAlshiekh 5 днів тому

    We learned about them in a lecture, but I did not understand anything... This video was very helpful in clarifying and simplifying the topic. Thank you very much🙏🙏❤️❤️I follow you from Syria.

  • @Doodle-cp6wt
    @Doodle-cp6wt 7 днів тому

    I appreciate your Informative lecture! Side note: I would recommend editing "7:40", as acetaminophen is not an NSAID (Non-Steriodal Anti-Inflammtory Drug).

  • @tonygarciAtla51
    @tonygarciAtla51 8 днів тому

    I use caffeine to my advantage, as I have class early morning, then I take a nap mid day. Thanks to the caffeine crash 🤷🏻‍♂️.

  • @subhashbathini7422
    @subhashbathini7422 14 днів тому

    Great video, thanks

  • @doesntfeellikehome4229
    @doesntfeellikehome4229 17 днів тому

    this lecture is what i want.. perfect

  • @MaramHassan17
    @MaramHassan17 18 днів тому

    You're amazing. Thank youuuu!!!!!

  • @hodafazaely2641
    @hodafazaely2641 20 днів тому

    Many thanks for it. You send important information as quickly as feasible.

  • @Amalistruzione
    @Amalistruzione 22 дні тому

    Amazing content. Thank you

  • @Mattbailey90
    @Mattbailey90 25 днів тому

    Great video ❤

  • @jamesk8s1
    @jamesk8s1 26 днів тому

    Amazing!

  • @amangandhi1182
    @amangandhi1182 26 днів тому

    Very good explanation. Continue making such videos.

  • @husbdndn6036
    @husbdndn6036 27 днів тому

    Do more videos please

  • @user-ni8cy9tn7c
    @user-ni8cy9tn7c Місяць тому

    I have been suffering from this disease since I was 15 years old and I am currently 27 years old. Is there a treatment? Please reply😢😢😢

  • @miless.-d.782
    @miless.-d.782 Місяць тому

    The way this Video explained this topic is insane. The graphical demonstration is just awsome

  • @vshshshsvsbbdizk
    @vshshshsvsbbdizk Місяць тому

    I am preparing for an presentation of car-t cells and I would like to thank you because your video helped me to understand everything clearly.

  • @bio366geethasankar7
    @bio366geethasankar7 Місяць тому

    🙏🙏🏻🥹

  • @KniDonovan
    @KniDonovan Місяць тому

    Thank you for the information. Medicare Medicare covers a pharmacological gene test FOR FREE. My life was hell dealing with doctors and medicines being over medicated and dealing with terrible side effects for decades because I had unrecognized pharmacological gene deletion and other malabsorption issues. I even had to see one time in my chart that a doctor noted I was being psychosomatic because I repeatedly tried to bring to their attention medicines were not working or having terrible effects. Try advocating for yourself after surgery when a pain medicine doesn't work and see how you will be treated unless you can show them how you metabolize medication's. It's not awesome. I got my test done through GeneSight. I am in no way affiliated. I just am so thankful for the information now and being able to work with my doctors.

  • @Omargharbi5038
    @Omargharbi5038 Місяць тому

    This is the best ed video that i watched in my life ⭐️⭐️⭐️⭐️

  • @olaabdallah3607
    @olaabdallah3607 Місяць тому

    Amazing explanation. You made this easy and clear. Thank you ❤❤

  • @debismita09
    @debismita09 2 місяці тому

    Omygod thankyou soo muchh😭🖐🏻

  • @hfof
    @hfof 2 місяці тому

    omg, the way how you illustrated everything is just beyond perfection. I hope you keep going, you've definitely helped so many people, and I hope you keep on making the same cool content. Thank you so much, love and guidance.

  • @LGRacing123
    @LGRacing123 2 місяці тому

    No tears in my eyes to cry.... No any feeling when Im breathing ... No nothing to do anything except prying .... Im alone in this world .... My cute son with this problem DMD.....so sad.... If therei is any energy hidden somewhere ... Please help to find success treatment for this .... As soon as possible ... Still have a tiny hope till last breath ......😪😪😪😪

  • @sabinabirabwa
    @sabinabirabwa 2 місяці тому

    very informative and helpful. thank you!

  • @DD-lj6io
    @DD-lj6io 2 місяці тому

    Great thanks for explaining

  • @radwan3505
    @radwan3505 2 місяці тому

    can you please tell us the website you are using to make animation and presentation

  • @guidaribeiromap
    @guidaribeiromap 2 місяці тому

    Excellent content. love it!

  • @anthonystipelcovich3763
    @anthonystipelcovich3763 2 місяці тому

    Just because you’re prescribed something doesn’t mean you have to take it. Also, whose fault is it if you take more than the prescribed amount?

  • @mussabm2981
    @mussabm2981 2 місяці тому

    Amazing channel pls don’t stop your narrative is so soo unique and grabs attention. I really watch so many medical, science-related channels but yours are currently the best i have watched. Your graphics. Your details and information are things you don’t see in other channels

  • @albrigo
    @albrigo 2 місяці тому

    As an experienced health professional, I'm impressed to see how a graduate student explains in a simple and educational yet scientific way such difficult pharmacological concepts. I encourage you to continue like that, and I am pleased to follow your videos!

  • @Negarnorz
    @Negarnorz 2 місяці тому

    this video and the information you collected are really amazing and useful. thank you for this brief explanation based on really good papers that you had chosen .

  • @Alex-mq8jb
    @Alex-mq8jb 2 місяці тому

    this was just great

  • @akk6783
    @akk6783 3 місяці тому

    Nice graphics and clear explanations.

  • @bellyvelly
    @bellyvelly 3 місяці тому

    that's literally what I've been looking for thank u ❤

  • @user-vu6wg2uu7r
    @user-vu6wg2uu7r 3 місяці тому

    Execellent

  • @dianelap67
    @dianelap67 3 місяці тому

    Is a stroke the same as an aneurysm? My daughter had one, when they operated she had another brain bleed, had it not been for that second bleed she would have survived. She could talk very slowly, she recognized us all, she smiled and joked with the doctor. After about 20 days after the operation is when the second bleed occurred this was the last time I could talk to her, she went into a vegetative state for many months where she was on and off a venting machine.

    • @Medicurio
      @Medicurio 3 місяці тому

      So sorry to hear about your daughter, my condolences. An aneurysm and a stroke are related but different concepts. An aneurysm can cause a hemorrhagic (bleeding) stroke if it ruptures, but strokes can be caused by other things like blockages of blood vessels.

    • @dianelap67
      @dianelap67 3 місяці тому

      @@Medicurio Thank you!

  • @amirhosseinrahbar9368
    @amirhosseinrahbar9368 3 місяці тому

    So accurate. Thank you

  • @theresamartinelli8844
    @theresamartinelli8844 3 місяці тому

    What happened to Ketoprofen for pain relief? I used it for mild to severe pain and it worked and was not a drug that was an addictive drug. Great content and the history is of the problem is fascinating.

    • @Medicurio
      @Medicurio 3 місяці тому

      Ketoprofen is an nonsteroid anti-inflammatory (NSAID) that is in the same family as other NSAIDs like aspirin and ibuprofen (Advil). From what I understand it is still available and used. It definitely is less potent than opioids for pain relief though and is usually only used for, as you suggested, mild/moderate pain and maybe severe pain for some.

  • @theresamartinelli8844
    @theresamartinelli8844 3 місяці тому

    It’s a great gift to make the complex understandable thank you for this information.

  • @theresamartinelli8844
    @theresamartinelli8844 3 місяці тому

    Great video and highly understandable for the common person to learn thank you.

  • @ikeoluwaonasanya7105
    @ikeoluwaonasanya7105 3 місяці тому

    BMT nurse here! This was so helpful! Thank you!

  • @LOL_MANN
    @LOL_MANN 3 місяці тому

    Last video rip

  • @gisselgreene
    @gisselgreene 3 місяці тому

    This is a beautiful and very informative video. Thank you! 😊 I have a family history of high blood pressure and cholesterol. I eat healthy my overall cholesterol is normal but the LDL was very high. I was placed on Atorvastatin now the LDL is low and my blood pressure is normal every day.

  • @whatsup968
    @whatsup968 4 місяці тому

    Went down a rabbit hole tonight. Thank you for explaining why naloxone doesn't have the same effect as an opioid like fentanyl even though it binds to the same receptors. Most explanations I found skipped over that. All they said was naloxone binds to the receptors in place of fentanyl and I was thinking "Wait, but how is that different than what fentanyl does?" Now I know binding to a receptor ≠ activating a receptor! Drug addiction and withdrawal are certainly a lot to overcome, to say that least. I feel for anyone dealing with it, and I am cheering for them, whether they are actively trying to be/are sober or not, to have true happiness and health

    • @BushyHairedStranger
      @BushyHairedStranger 2 місяці тому

      Life liberty & the pursuit of happiness means the right for adults to enjoy any molecules of their choice in the world without fear of being investigated! arrested! kidnapped! or thrown into a cage by tyrants with badges & guns! Humans have used Opiates for thousands of years without “addiction” issues until Harry Anslinger of the Federal Bureau of Dangerous Drugs got involved! The FBODD would become the DEA they applied the Nazi’s anti-drug ideologies here in the USA in the 1940’s. So the Number of Opiate Addictions exploded immediately after that happened…wonder why….

  • @user-mc4xs6hi8n
    @user-mc4xs6hi8n 4 місяці тому

    Very easy way to Understand Difficult Topic by medicur

  • @pacifiquebusiness
    @pacifiquebusiness 4 місяці тому

    Great video 🩺🙏

  • @MarkBarners
    @MarkBarners 4 місяці тому

    caffeine lowers blood flow to the brain between 15-40% - so its not really healthy for you as it makes you ignore that your body is tired and need sleep or rest. Look it up "Does coffee lower your blood flow to the brain"

  • @christianwellness4363
    @christianwellness4363 4 місяці тому

    great explanation ,now i understand the chemistry behind addiction better . thank you :)

  • @pacifiquebusiness
    @pacifiquebusiness 4 місяці тому

    Thank You 🩺

  • @edm1852
    @edm1852 4 місяці тому

    istg this video is so well made... thank you good work